What is CBG and Why is Cannabigerol Considered the “Mother” Cannabinoid?

CBG or cannabigerol is one of the main cannabinoids found in the Cannabis sativa plant and is often referred to as the “mother cannabinoid” because it is from it that other cannabinoids such as CBD, THC and other compounds develop. First discovered in 1964 by Israeli scientist Raphael Mechoulam , CBG is only present in low concentrations in mature hemp, as it rapidly converts into other cannabinoids during the growth phase of the plant.

CBG is a non-psychoactive and non-intoxicating cannabinoid , meaning it does not produce the “high” synonymous with THC. Because it is present at low levels (usually less than 1%) in most cannabis strains, CBG is considered a minor cannabinoid. Surprisingly, however, THC and CBD start out as CBG: it is, in fact, their chemical parent. Cannabis plants produce cannabigerolic acid ( CBGA ), the precursor to the three main cannabinoid lineages (pictured below): tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid (CBCA).

Specific enzymes in the plant break down CBGA and “route” it to one of three lanes. The acids, when exposed to ultraviolet light or heat, magically become the cannabinoids we know: THC and CBD. In most strains, CBGA is immediately converted to THCA or CBDA. Therefore, more THC means less CBG and CBD (and vice versa) due to the nature of these compounds and their synthesis.

To get higher yields of CBG, breeders are experimenting with genetic manipulation and crossbreeding plants. For example, Subcool Seeds is crossbreeding strains to produce higher CBG content. Scientists can also extract higher levels of CBG from live plants by timing the extraction optimally, with about six weeks into an eight-week flowering cycle appearing to be the perfect time. A medicinal strain called Bediol is produced this way by the Dutch company Bedrocan BV Medicababis .

The human body’s built-in endocannabinoid system (eCS) works to keep the body in its balanced state of homeostasis. While there are specific details about how cannabinoids work, in general the endocannabinoid system performs several functions specific to each area of ​​the body. For example, in the case of injury, the eCS can help regulate immune cells to limit inflammation.

What Are the Effects of CBG on the Endocannabinoid System?

The endocannabinoid system is a complex network of receptors in the human body, including the main CB1 and CB2 receptors . These receptors play a vital role in regulating bodily functions such as mood, appetite, pain, and the immune system. In the case of CBG, it has been found to act directly on the CB1 and CB2 receptors , influencing these functions and potentially contributing to overall well-being.

In particular, it has been shown that CBG can interact with the CB1 and CB2 receptors without causing psychoactive effects, as happens with THC . This characteristic makes CBG interesting for those looking for a therapeutic option without the “high” associated with cannabis. In addition, CBG can help inhibit the absorption of certain neurotransmitters, such as GABA, contributing to the reduction of muscle tension and improvement of mood.

What Are the Beneficial Properties of CBG?

Recent studies suggest that CBG has numerous beneficial properties , including anti-inflammatory , antioxidant , and analgesic properties . These characteristics could make CBG useful in treating a wide range of medical conditions and symptoms.

CBG has been shown to work as a natural anti-inflammatory, helping to reduce inflammation and pain associated with chronic conditions. Additionally, due to its antioxidant properties, CBG may protect cells from free radical damage, contributing to overall health. This therapeutic potential is attracting interest from the scientific community, which continues to study the medical applications of cannabigerol.

CBD and CBG: What Are the Differences Between Cannabigerol and Cannabidiol and Which Is More Effective?

CBG and CBD are two distinct cannabinoids found in the cannabis plant , and while they share some properties, they have different effects and mechanisms of action. While CBD is known for its relaxing and anti-anxiety properties, CBG appears to have a greater impact on specific areas of the nervous system, such as reducing muscle tension and protecting neurons.

Another important difference is concentration. The cannabis plant typically contains more CBD than CBG , making the latter rarer and more difficult to extract in large quantities. Some studies suggest that CBG may be particularly useful for treating conditions such as glaucoma and Huntington's disease , due to its ability to reduce intraocular pressure and its potential neuroprotective action.

Does CBG Have Psychotropic Effects Like THC?

Unlike THC , which is known for its psychoactive effects , CBG does not have psychoactive effects. This means it does not cause feelings of euphoria or altered perception, making it a safe option for those looking for the benefits of cannabis sativa without the psychoactive side effects.

This feature is very important for those who want to use cannabinoids for therapeutic purposes without incurring psychoactive effects that could interfere with daily life. Thanks to this peculiarity, CBG is gaining popularity as a natural option for the treatment of various disorders.

What Are The Beneficial Effects of CBG for Glaucoma Treatment?

One of the most promising uses of CBG is in the treatment of glaucoma. Studies have shown that CBG can reduce intraocular pressure , a critical factor in the management of glaucoma. This ability to reduce eye pressure may prevent damage to the optic nerve, which is essential for maintaining good vision.

Glaucoma treatment is just one area where CBG has shown promise, and researchers continue to explore how cannabigerol can be integrated into existing therapies to offer additional benefits to patients.

How Do CBG Crystals Work and How to Use Them?

CBG crystals are a pure and concentrated form of cannabigerol , obtained through advanced extraction processes. These crystals are particularly appreciated for their purity and effectiveness, as they contain only CBG and no other cannabinoids or impurities.

CBG crystals can be used in a variety of ways: they can be dissolved in CBD oil to create a CBG and CBD combination oil , vaporized, or added to edibles to benefit from the effects of CBG . This form of cannabinoid cbg is ideal for those who want to precisely dose the amount of cannabigerol and monitor its effects.

How to Choose the Best CBD Oil vs. CBG Oil?

CBG oil is one of the most popular forms of this cannabinoid. However, it is important to choose a quality oil to get the most benefits. When choosing a CBG oil , it is essential to check the purity of the product, the percentage of CBG it contains, and the possible presence of other cannabinoids such as CBD and THC .

Many CBG oils also contain CBD to take advantage of the so-called “entourage effect,” or the synergistic interaction between different phytocannabinoids . This combination can amplify the benefits of CBG and offer a wider range of therapeutic properties. For those who prefer a THC- free product , it is important to check that the oil has been laboratory tested to ensure it is free of this psychoactive cannabinoid .

What is the Therapeutic Potential of CBG?

The potential of CBG has been recognized in several areas of medicine, including its application to treat neurodegenerative conditions such as Huntington’s disease . Studies suggest that CBG may protect nerve cells from damage and reduce muscle tension in patients with the condition. Additionally, its anti-inflammatory and analgesic properties make it promising for the treatment of other chronic diseases.

Furthermore, CBG has shown potential beneficial effects in the gastrointestinal area as well. Some studies suggest that cannabigerol may have a positive effect in the management of inflammatory bowel diseases, thanks to its ability to reduce inflammation.

CBG and CBD: An Example of Cannabinoid Synergy

CBG and CBD often work best when used together, thanks to the aforementioned entourage effect . This combination can amplify the beneficial properties of both cannabinoids, offering a more well-rounded therapeutic approach. For example, CBD oil with the addition of CBG may provide greater efficacy for the relief of chronic pain, inflammation, and anxiety. The synergy between CBD and CBG has been shown to increase the potency of both cannabinoids without causing psychoactive effects, as is the case with THC.

Many users therefore prefer products that contain both CBD and CBG , such as CBD oil enriched with CBG , as this type of formulation can potentially cover a wider range of ailments. While CBD is known for its calming and anti-anxiety effects, CBG adds additional anti-inflammatory and neuroprotective properties, making these two cannabinoids a winning combination for those seeking a natural approach to wellness.

Can CBG Have Side Effects?

Although CBG is generally well tolerated and safe, some people may experience mild side effects such as dry mouth or mild fatigue, especially when taken in high doses. However, compared to other cannabinoids such as THC , CBG does not cause psychoactive effects , making it safer and more suitable for everyday use, including while working or driving.

As with any supplement or natural product, it is advisable to start with a low dose and gradually increase, monitoring personal reactions.

The Future of CBG in Research and Medical Applications

CBG is receiving increasing attention from the scientific community for its potential in multiple therapeutic fields. Research on CBG is still in the early stages, but preliminary results are very promising. Scientists are exploring the use of CBG to treat a wide range of conditions, including neurodegenerative diseases, chronic inflammation, and ocular disorders.

CBG ’s potential as a natural and safe alternative to synthetic pharmaceuticals could transform the health and wellness industry in the coming years. With more and more studies focusing on this cannabinoid , it is likely that we will soon see further developments and new applications of CBG in the clinical setting.

Conclusion

In conclusion, cannabigerol (CBG) is emerging as a cannabinoid of great interest for its therapeutic potential and its many beneficial properties. First discovered in the 1960s, CBG helps reduce inflammation and is known for its strong anti-inflammatory and analgesic properties , benefiting from particular antidepressant and analgesic effects with potential also pain-relieving effects . Several studies suggest that cannabigerol could be used to treat diseases such as Huntington's Chorea and to manage other inflammatory pathologies thanks to its beneficial anti-inflammatory and analgesic properties .

CBG has also attracted particular attention for its possible use as a cannabinoid in association with CBD and THC , enhancing the therapeutic contribution of both. The relationship with the use of cannabigerol has shed light on the potential antidepressant effects that may involve not only CBG but also other cannabinoids . With drops of CBG oil it is possible to benefit from a cannabinoid that would be the most effective in the management of inflammation and chronic pain.

In essence, CBG itself offers a very important property in the field of natural well-being, with potentially beneficial effects for those seeking an alternative to traditional therapies.